Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.5
USERS' SCORE
Good
Based on 14 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Serving Per Container: 60
Amount Per Serving
%DV
BioCell Collagen® (Hydrolyzed Chicken Sternal Cartilage Extract) providing
1 g (1,000 mg)
**
Hydrolyzed Type II Collagen
570 mg
**
Chondroitin Sulfate
190 mg
**
Hyaluronic Acid
95 mg
**
Top Medical Research Studies
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
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9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
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9
We explored a creative approach to treat rheumatoid arthritis, focusing on a new delivery method for tacrolimus using hyaluronic acid-coated nanogels.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
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Most Useful Reviews
9
Consistent results achieved
70 people found this helpful
I ordered this collagen on my doctor's advice. At 38, with a diagnosis of coxarthrosis, I took 2 capsules each morning for three months. I saw results after a month and a half, with discomfort fading away. I now take it once a year for prophylaxis and will continue ordering.
Read More
9
Significant improvements noted
60 people found this helpful
I purchased this to enhance joint health, knowing collagen can help with inflammatory conditions. Since starting it on 06.01.22, I have felt much better by 17.01. I can confidently say it has helped!
Read More
7.5
Positive joint support
2 people found this helpful
This isn't my first purchase for my parents; they found this collagen beneficial for joint support. Notably, the discomfort and joint noises decreased within the second week of use. It hydrates cartilage, enhancing its elasticity. The quality is excellent, and the effects are undeniable.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.5
- All Researches
9.5
We explored a novel injectable hydrogel designed to treat rheumatoid arthritis, which often causes joint lubrication issues and cartilage damage. This hydrogel incorporates modified hyaluronic acid and nanozymes that work together to reduce inflammation and promote cartilage repair.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
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9
We explored how the collagen supplement BD400 affects rheumatoid arthritis (RA) using a collagen-induced arthritis rat model.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
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9
We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
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9
We aimed to tackle the side effects of long-term use of tofacitinib, a well-known treatment for rheumatoid arthritis. By creating hyaluronic-acid-coated transethosomes, we delivered tofacitinib directly to affected areas, enhancing efficacy while reducing side effects. Our results showed significant anti-inflammatory effects, with marked reductions in inflammatory markers in treated rats compared to conventional delivery methods. This suggests that our targeted approach may offer a promising alternative for managing rheumatoid arthritis with fewer systemic impacts.
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9
Innovative dual-drug treatment examined
We explored the potential of hyalurosomes that combine dexamethasone and luteolin as a treatment for rheumatoid arthritis. In a study using a rat model, we observed significant reductions in inflammatory markers like TNF-α and MDA, suggesting these dual drug-loaded hyalurosomes could effectively decrease inflammation and swelling in joints.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
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User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Consistent results achieved
70 people found this helpful
I ordered this collagen on my doctor's advice. At 38, with a diagnosis of coxarthrosis, I took 2 capsules each morning for three months. I saw results after a month and a half, with discomfort fading away. I now take it once a year for prophylaxis and will continue ordering.
Read More
9
Significant improvements noted
60 people found this helpful
I purchased this to enhance joint health, knowing collagen can help with inflammatory conditions. Since starting it on 06.01.22, I have felt much better by 17.01. I can confidently say it has helped!
Read More
7.5
Positive joint support
2 people found this helpful
This isn't my first purchase for my parents; they found this collagen beneficial for joint support. Notably, the discomfort and joint noises decreased within the second week of use. It hydrates cartilage, enhancing its elasticity. The quality is excellent, and the effects are undeniable.
Read More
9
Effective for arthritis
1 people found this helpful
Ordering for the third time I'm ordering for the third time. I really like this collagen; it helps with arthritic knees. It does not make me feel unwell, but I take it an hour before meals or two hours after, alongside orange juice.
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7.5
Improved joint condition
5 people found this helpful
Good quality Type 2 collagen is the main structural protein of cartilage. I ordered it for my husband, who has joint and intervertebral disc problems. His condition has improved, and the crunching in his joints has disappeared. I will be ordering more.
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Frequently Asked Questions
9
Consistent results achieved
70 people found this helpful
I ordered this collagen on my doctor's advice. At 38, with a diagnosis of coxarthrosis, I took 2 capsules each morning for three months. I saw results after a month and a half, with discomfort fading away. I now take it once a year for prophylaxis and will continue ordering.
9
Significant improvements noted
60 people found this helpful
I purchased this to enhance joint health, knowing collagen can help with inflammatory conditions. Since starting it on 06.01.22, I have felt much better by 17.01. I can confidently say it has helped!
7.5
Positive joint support
2 people found this helpful
This isn't my first purchase for my parents; they found this collagen beneficial for joint support. Notably, the discomfort and joint noises decreased within the second week of use. It hydrates cartilage, enhancing its elasticity. The quality is excellent, and the effects are undeniable.
7.5
Improved joint condition
79 people found this helpful
I have ordered this product multiple times. I took 2 capsules each morning for three months. After a month and a half, I noticed a significant improvement as the crackling and discomfort in my joints disappeared. Now, I take it annually for prevention.
9
Sleep quality enhanced
2 people found this helpful
The hydrolytic type 2 collagen arrived faster than expected. I take it for medical reasons, and within a week, I noticed improved sleep quality and an increase in body protein levels. Only positive effects so far!
7
Knee pain relief
It helps my sore knee; I stopped for a month, and the pain returned. I am ordering and using it again.
9
Effective for arthritis
1 people found this helpful
Ordering for the third time I'm ordering for the third time. I really like this collagen; it helps with arthritic knees. It does not make me feel unwell, but I take it an hour before meals or two hours after, alongside orange juice.
7.5
Joint improvement
I ordered it for my mum. She mentioned that collagen is beneficial for joints and has noticed improvements.
8
Skin and joints improved
1 people found this helpful
Great! I am very pleased, as it also improved the skin around my eyes. If it has such a positive effect externally, I believe it is helping my joints as well. Highly recommend!
7.5
Effective for arthritis
The quality is excellent! My mother takes it for arthritis as her knees hurt significantly. I ordered it along with chondroitin and glucosamine, and the results are pleasing.
9
We explored how the collagen supplement BD400 affects rheumatoid arthritis (RA) using a collagen-induced arthritis rat model.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
8
We assessed the effects of collagen supplements, specifically strain CCFM1074, on arthritis in rats. This study utilized a robust method that examined the immune responses, gut microbiota, and various metabolites.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
8
This study delves into a creative approach for treating rheumatoid arthritis (RA) using a viral-mimicking delivery system. By incorporating hyaluronic acid into a polyplex that carries the inflammation-fighting drug Cyclosporin A, we observed effective targeting and drug release directly in affected joints.
The findings showed that this system not only helps reduce inflammation but also promises prolonged drug action within the body. Overall, these results suggest a potential breakthrough in delivering treatments for RA and possibly other autoimmune conditions in a more efficient manner.
The findings showed that this system not only helps reduce inflammation but also promises prolonged drug action within the body. Overall, these results suggest a potential breakthrough in delivering treatments for RA and possibly other autoimmune conditions in a more efficient manner.
References
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. doi:10.3389/fimmu.2021.680073
- Wei SJ, Zhang Q, Xiang YJ, Peng LY, Peng W, et al. decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. Pharm Biol. 2021;59:262. doi:10.1080/13880209.2021.1876100
- Jhun J, Moon J, Ryu J, Shin Y, Lee S, et al. Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting. PLoS One. 2020;15:e0241080. doi:10.1371/journal.pone.0241080
- Gusmao-Silva G, Aguiar SLF, Miranda MCG, Guimarães MA, Alves JL, et al. Hsp65-Producing Prevents Antigen-Induced Arthritis in Mice. Front Immunol. 2020;11:562905. doi:10.3389/fimmu.2020.562905
- Wu J, Liu X, Chan CO, Mok DK, Chan SW, et al. Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats. J Ethnopharmacol. 2014;157:45. doi:10.1016/j.jep.2014.09.026
- Nowak B, Ciszek-Lenda M, Sróttek M, Gamian A, Kontny E, et al. Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice. Arch Immunol Ther Exp (Warsz). 2012;60:211. doi:10.1007/s00005-012-0170-5
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. doi:10.1038/s41467-025-58059-z
- Tang W, Huang X, Yi YD, Cao F, Deng M, et al. Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway. J Nanobiotechnology. 2025;23:89. doi:10.1186/s12951-024-03082-3
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. doi:10.1016/j.colsurfb.2025.114497
- Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073
- Liu X, Chen X, Fei Y, Zhang J, Yue O, et al. Locally Injectable, ROS-Scavenging, and ROS-/pH-Responsive Polymeric-Micelles-Embedded Hydrogels for Precise Minimally Invasive and Long-Lasting Rheumatoid Therapy. Adv Healthc Mater. 2025;14:e2403579. doi:10.1002/adhm.202403579
- Papp FR, Katko M, Csiki R, Galgoczi E, Molnar Z, et al. Characteristics of Hyaluronan Metabolism During Myofibroblast Differentiation in Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2024;65:13. doi:10.1167/iovs.65.13.13
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiO₂ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. doi:10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. doi:10.1186/s12951-024-02784-y
- Xu M, Fu T, Zhang C, An Z, Yan J, et al. Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy. J Control Release. 2024;375:60. doi:10.1016/j.jconrel.2024.08.046
- Deng YS, Shen XY, Long MT, Zheng H, Li B, et al. [MMPs/pH synergically responsive XTS-Prussian blue nanoparticles inhibiting proliferation and migration of RAFLS assisted with laser irradiation]. Zhongguo Zhong Yao Za Zhi. 2024;49:2906. doi:10.19540/j.cnki.cjcmm.20240304.303
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. doi:10.1016/j.ijpharm.2024.124449
- Liu X, Zhang Q, Cao Y, Hussain Z, Xu M, et al. An Injectable Hydrogel Composing Anti-Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis. Adv Healthc Mater. 2024;13:e2304668. doi:10.1002/adhm.202304668
- Zhu H, Huang D, Wang J, Zhao Y, Sun L. Viral Mimicking Polyplexes as Hierarchical Unpacking Vectors for Rheumatoid Arthritis Treatment. Adv Sci (Weinh). 2024;11:e2402888. doi:10.1002/advs.202402888
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. doi:10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. doi:10.1021/acs.biomac.4c00556
